P-Glycoprotein Inhibitor

Any ideas for an effective PGP inhibitor that I can buy OTC or as a supplement? So far I only know of Milk Thistle and Star Fruit and they are very weak inhibitors.

I read something about artichokes a while back.
It went on about milk thistle and artichokes and a few other things doing the same things at varying degrees of potency and effectiveness. I remember a mention of PGP inhibition somewhere in there Cyclo.
Will try to hunt down where the article was for you.

Nate

Geez this is going back to Pharmacodynamics 101.

Many drugs inhibit PGp examples are ketoconazole and cyclosporine.

Unfortunately the amounts you have to take to initiate the kind of effect you're looking for will result in the toxicity of those drugs. (plus they're not OTC).

Even an extensive medline search gave me the same results you no doubt got on google. It lists a lot of very good articles (not the anecdotal pseudoscience crap google usually spews out).

I know we give the guys on TB meds (as well as those on certain anti-psychotics high doses of thiamine (100mg BD) to aid the liver given the high Rifampicin doses the TB guys take.

Thiamine is already in Essentiale but it won't hurt to increase the dose.

Sorry bud. Not too much help but suspect a dead end as someone somewhere would have stumbled onto this.

Unfortunately no studies for this would be funded as it involves the use of excessive dosages of "illegal or banned drugs". Even in the old East Germany and Russia they were so fixated on results the athletes safety wasn't a concern. Most didn't even know that they were taking AAS eg Turinabol.

According to the FDA Website these are some PGP-Inhibitors worth looking at (and my thoughts):

Itraconazole, ketoconazole (used for fungal infections and with some nasty side effects)
lopinavir/ritonavir / indinavir (HIV)
clarithromycin (antibiotic I am immune to)
erythromycin, azithromycin (antibiotic)
conivaptan (brand name Vaprisol which is an antidiuretic hormone)
Verapamil, felodipine (Oral anti-hypertensive. The PGP effect is mostly from the calcium blocking effect. These are viable options.)
diltiazem (I wish lol)
dronedarone, Quinidine, amiodarone (cardiac arrhythmia. Quinidine seems to be a preferred drug for the purpose of PGP-Inhibition by manufacturers, who combine it with others for this purpose.)
ranolazine (fuark no!)

I am researching this for other reasons. The fact that AAS is also metabolized by PGP is not that interesting.

Pyroclasm wrote: According to the FDA Website these are some PGP-Inhibitors worth looking at (and my thoughts):

Itraconazole, ketoconazole (used for fungal infections and with some nasty side effects)
lopinavir/ritonavir / indinavir (HIV)
clarithromycin (antibiotic I am immune to)
erythromycin, azithromycin (antibiotic)
conivaptan (brand name Vaprisol which is an antidiuretic hormone)
Verapamil, felodipine (Oral anti-hypertensive. The PGP effect is mostly from the calcium blocking effect. These are viable options.)
diltiazem (I wish lol)
dronedarone, Quinidine, amiodarone (cardiac arrhythmia. Quinidine seems to be a preferred drug for the purpose of PGP-Inhibition by manufacturers, who combine it with others for this purpose.)
ranolazine (fuark no!)

I am researching this for other reasons. The fact that AAS is also metabolized by PGP is not that interesting.

As said the dosages you use would have to be quite high which will generally precipitate other side effects.

Can write a biopic on each but the most important ones in my opinion:

The Calcium Channel blockers are dangerous drugs. Especially Verapamil. It can flatline you. It was a miracle drug back in the day but Ca2+ Channel blockers like Amlodipine are much more widely used. Mostly reserved for Arrhythmias.

Felodipine is safer, but like saying a leopard is safer than a lion.

As for Amiodarone - stay the fk away from it. It will seriously screw with your thyroid and it can cause gyno.

Give me solutions dammit!!