GW-501516 from Liquid-Pharma

I'm supposed to start 20mg p.d. tomorrow. Now I'm a bit worried.

I also wantes to start 20mg from monday and i am also worried now.

I was on it for a week, but since reading all this I've put it on hold until everything becomes a bit clearer.

Good day gents, asked my proff and he gave me a real shitty answer so had to go check myself. His response was if its carcinogenic stay away, which is a logical response as opposed to encouraging someone to taking it. Not using is better i guess but people smoke and cigarettes are full of carcinogenics and people dont lose their minds when spoken of, also i read up on the studies and the rats were given very high doses ranging from 5mg/kg to 20mg/kg per day which in a 100kg human would be around 500mg-2000mg a day, after seeing this and reading recommended dosages it seems like 20mg a day is a tiny amount compared to the experimental values . But my opinion is the same, if its got the potential to cause cancer then dont use it. Does this board encourage people to smoke?? No( i hope)

Hope that makes sense....

GeneralJ wrote: Good day gents, asked my proff and he gave me a real shitty answer so had to go check myself. His response was if its carcinogenic stay away, which is a logical response as opposed to encouraging someone to taking it. Not using is better i guess but people smoke and cigarettes are full of carcinogenics and people dont lose their minds when spoken of, also i read up on the studies and the rats were given very high doses ranging from 5mg/kg to 20mg/kg per day which in a 100kg human would be around 500mg-2000mg a day, after seeing this and reading recommended dosages it seems like 20mg a day is a tiny amount compared to the experimental values . But my opinion is the same, if its got the potential to cause cancer then dont use it. Does this board encourage people to smoke?? No( i hope)

Hope that makes sense....

Hey, GeneralJ. Just a side note: you calculations are a bit off. The mg/kg in the rat studies won't directly track for humans According to THIS and posted HERE .

If I remember my calculations, then the min dose is something closer to 60mg/day

My calculations say it´s 0,405mg/kg - 1,622mg/kg for a human adult. This means for a 60kg adult the equivalent dosages were 24mg - 97mg.

Pyroclasm wrote: My calculations say it´s 0,405mg/kg - 1,622mg/kg for a human adult. This means for a 60kg adult the equivalent dosages were 24mg - 97mg.

Hey, Pyro. Your calculations are correct but the GW studies used rats, not mice. As far as I can tell the Km factor for rats is 6 , and not 3.

O okay I see bro thought we used mice! So the equivalent dosages were double that. 0,8mg/kg - 3,2mg/kg. In a 60kg adult it was equivalent to 48mg - 194mg.

Correct

Hey Guys

Any more news on the carcinogenic links with GW

Update...

Muscleaddict wrote: Peptide. Here's a link to a thesis on the stuff: CLICK

...and my breakdown of what the thesis say's GW501516 does:

The whole thing is about how GW501516 affects the metabolism of fatty acids. How it activates receptors responsible for regulating the expression of various genes involved in the metabolism of carbs, cholesterol and lipids as well as formation of new fat cells.

In the thesis they look at GW's effect on acetyl-CoA. If you eat more than you burn then your body produces too much acetyl-CoA and this is stored as fat. GW drastically reduces the enzyme ACC that's responsible for resulting in acetyl-CoA being stored as fat.

The data also shows that GW501516 upregulates CPT transcription. WTF is that? :blink: This facilitates the transport of fatty acids into mitachondria. These are the cells that turn fatty acids into usable energy where otherwise they could have been stored as fat.

Next it shows that GW501516 drastically reduces LPL gene activation. WTF? :blink: Lipoprotein Lipase is also involved in dreaded fat storage. Something about regulating much fatty acids are stored in adipose tissue. So reducing LPL means reducing fat storage.

The thesis also says how PPAR agonists like GW501516 (and they mention another I never heard of -GW610742) help regulate the 'reverse cholesterol transport process'. This is where our good HDL cholesterol moves bad LDL cholesterol from tissues in the body back to the liver where excess cholesterol is eliminated. Very good.

Also worth a mention is that GW501516 has been linked to possibly being carcinogenic in a study on mice. The doses use on the animals equate to about 10x the normal dose that we would take, and there is no evidence either way to prove that there is/isn't a risk. But as far as I know it has not been linked to cancer in humans.

Any update regarding the GW-501516?

zhattingh wrote: Any update regarding the GW-501516?

What exactly do you need an update on? Your question is unclear.

Sorry Admin,

My mistake!

What I wanted to ask: how is everyones expierences, results and how are they doing etc.
in a weird way I am very intrested in peoples expierences. Each and every person expieriences it different.

Is there any concern regarding cancer thats spreading according to tests that was done on mice?

yes but apparently tribilus counteracts the negetive effects.

There is no clinical evidence of it being carcinogenic in humans but good to play it safe. The only evidence is from rodent studies using extremely high doses. Megusta is right about the tribulus as it is a COX-2 inhibitor.

The theory is that GW501516 increases the risk for cancer in rodents due to high expression of these COX-2 enzymes. So taking a COX-2 inhibitor such as tribulus or even aspirin should counter that to some extent.

Thanks guys

Hi Guys.

We can revive this topic. I have been emailing Liquid Pharmaceuticals.
LP has confirmed a Batch of GW is about 4 weeks out. For us to try and for them to test demand. If demand is good they will bring it back along with a SARMS or two.

I am in. Counting coins already.
Groete
Die Bul.

Please LP!!! Bring it back!

@ Admin.
Sorry to bother bud. Did you ever get around to writing a drug profile on GW?

Rooi Bul 86 wrote: @ Admin.
Sorry to bother bud. Did you ever get around to writing a drug profile on GW?

No, I didn't really research it enough to know much about it other than how to use it. Maybe you would be interested in writing a profile?

I would see it as an honour and privilege.

But do do not have the faintest idea of how to go about it. As you know I am not a thech wizz like you guys.

Maybe we can get in contact to discuss the details?

The best articles comes from personal use. The second comes from finding and reading as much as you can about this. Then look for medical discussions around it then put a draft together and take it from there.

Thanks Pump.

I will make sure I use from the new batch coming will get enough. Then while I use and experiment I will build up a profile