Tamoxifen causes cancer. True?

Tamoxifen is a drug that binds to your estrogen receptors. Therefore it was thought that it could prevent excess estrogen binding, hence halting cancer from forming. It is generally prescribed to high-risk women to prevent breast cancer, and is usually taken for five years.

However, Tamoxifen has been found to cause cancer instead. According to a study published in the International Journal of Gynecological Cancer, the treatment of breast cancer with tamoxifen results in an increased risk of uterine cancer incidence and mortality.

This is just one in a growing line of studies published, raising serious concerns about the increased risk of uterine cancer for women who take tamoxifen as a cancer preventive drug. Despite these concerns, tamoxifen is still on the market.

Yes bro this is true, there is more than one aspect to this though. The cancer you are refering to is a result of the Selective Receptor Modulating effects of tamoxifen. Since it is an estrogen antagonist in breast, it is very useful for treating estrogen responsive breast cancer. However it is an estrogen agonist in the endometrium and thus promotes growth in this region, and may promote cancer. However the chances of a young lady having markers for breast cancer and endometrrial cancer are rare, however it is a valid concern for females members planning to use this drug.

The other aspect more relevant to us men is that tamoxifen has the ability to bind DNA irreversably. This does not occur frequently, and there is lots of junk DNA to bind, but as with all the other carcinogenic compounds we come into contact with in our daily bump and grind if it binds an important growth regulating gene this may result in an oncogenic mutation. It is a small risk but one we must all be aware of when using SERMs. In particular the liver comes under stress when this compound is used at the end of a cycle.

These, I think are primary reasons why tamoxifen should be used for short stints and not long periods of time.

Inja wrote:

Yes bro this is true, there is more than one aspect to this though. The cancer you are refering to is a result of the Selective Receptor Modulating effects of tamoxifen. Since it is an estrogen antagonist in breast, it is very useful for treating estrogen responsive breast cancer. However it is an estrogen agonist in the endometrium and thus promotes growth in this region, and may promote cancer. However the chances of a young lady having markers for breast cancer and endometrrial cancer are rare, however it is a valid concern for females members planning to use this drug.

The other aspect more relevant to us men is that tamoxifen has the ability to bind DNA irreversably. This does not occur frequently, and there is lots of junk DNA to bind, but as with all the other carcinogenic compounds we come into contact with in our daily bump and grind if it binds an important growth regulating gene this may result in an oncogenic mutation. It is a small risk but one we must all be aware of when using SERMs. In particular the liver comes under stress when this compound is used at the end of a cycle.

These, I think are primary reasons why tamoxifen should be used for short stints and not long periods of time.

What are the chances with 4 week pct after a cycle? and is clomid then perhaps a better option for pct?

Both SERMs bind DNA so no.

The chances with a 4-6 week PCT use of tamoxifen are very rare. Of course each time we use the drug after each cycle our chances go up because we increase the total time spent on on the drug in our lifetimes.
But the women studied for cancer risk are on these drugs for years to treat their breast cancer, and the incidence of developing a second cancer is very rare.

It's just something to keep in the back of your mind. Knowledge is power.